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    Please use this identifier to cite or link to this item: http://ir.fy.edu.tw/ir/handle/987654321/10120

    Title: Comparative investigations of genotoxic activity of five nitriles in the comet assay and the Ames test
    Authors: Wu,Jong-C.;Hseu,You C.;Chen, Chin-H.;Wang, Shu-H.;Chen, Ssu. C.
    Contributors: 輔英科技大學 應用化學及材料科學系
    Keywords: Nitriles;The modified Ames test;The comet assay;Genotoxicity
    Date: 2009-09-30
    Issue Date: 2010-11-18 15:02:41 (UTC+8)
    Abstract: Two short-term assays, the modified Ames test and the comet assay, were carried out to evaluate the genotoxicity of five nitriles (acetonitrile, propionitrile, methacrylonitrile, butyronitrile, and benzonitrile). With the comet assay, all the nitriles studied were found to induce the genotoxicity in human lymphocytes and Hep G2 cells. Except for butyronitrile, the genotoxic potency in lymphocytes was more pronounced than that in Hep G2 cells, and the rank order of genotoxicity induced by these five nitriles in lymphocytes was different from that in Hep G2 cells, indicating that the pathways leading to genotoxicity in both types of cells were different. In the modified Ames test, no tested nitriles showed mutagenic activity on Salmonella typhimurium strain TA 98 and TA 100 with and without metabolic activation.Comparing the results obtained from both tests in this study, the comet assay seems to be more sensitive than the modified Ames test. Thus, the comet assay can be used to detect the genotoxicity of all nitriles.
    Relation: Journal of Hazardous Materials,Volume 169, Issues 1-3, Pages 492-497
    Appears in Collections:[應用化學及材料科學系] 期刊論文

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