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    Please use this identifier to cite or link to this item: http://ir.fy.edu.tw/ir/handle/987654321/9615


    Title: Combined effects of terazosin and genistein on a metastatic hormone-independent human prostate cancer cell line.
    Authors: Chang,Kee-Lung;Cheng, Hsiao-Ling;Huang,Li-Wen;Hsieh,Bau-Shan;Hu,Yu-Chen;Chih,Tsai-Tung;Shyu,Huey-Wen;Su,Shu-Jem
    Contributors: 輔英科技大學 健康美容學位學程
    Keywords: Genistein;Terazosin;Prostate cancer;Apoptosis;Vascular endothelial growth factor (VEGF)
    Date: 2009-04-01
    Issue Date: 2010-11-11 11:21:37 (UTC+8)
    Abstract: Metastatic prostate cancer progresses from androgen-dependent to androgen-independent. Terazosin, a long-acting selective α1-adrenoreceptor antagonist, induces apoptosis of prostate cancer cells in an α1-adrenoreceptor-independent manner, while genistein, a major soy isoflavone, inhibits the growth of several types of cancer cells. The present study was designed to test the therapeutic potential of a combination of terazosin and genistein using a metastatic, hormone-independent prostatic cancer cell line, DU-145.

    Terazosin or genistein treatment inhibited the growth of DU-145 cells in a dose-dependent manner, whereas had no effect on normal prostate epithelial cells. Addition of 1 μg/ml of terazosin, which was inactive alone, augmented the growth inhibitory effect of 5 μg/ml of genistein. Co-treatment with terazosin resulted in the genistein-induced arrest of DU-145 cells in G2/M phase being overridden and an increase in apoptotic cells, as evidenced by procaspase-3 activation and PARP cleavage. The combination also caused a greater decrease in the levels of the apoptosis-regulating protein, Bcl-XL, and of VEGF165 and VEGF121 than genistein alone.

    In conclusion, the terazosin/genistein combination was more effective in inhibiting cell growth and VEGF expression as well as inducing apoptosis of the metastatic, androgen-independent prostate cancer cell line, DU-145, than either alone. The doses used in this study are in lower and nontoxic anticancer dosage range, suggesting this combination has potential for therapeutic use.
    Relation: Cancer Letters 276(1),14-20
    Appears in Collections:[健康美容系] 期刊論文

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