Aim.: This paper is a report of a study of the coping experiences of Taiwaneseadolescents with cancer.Background.: Cancer treatments have adverse effects and negatively affect adolescents’lives. Psychological coping strategies are antecedents to adjustment. Little isknown about the essential structure of the coping experience in adolescents withcancer.Method.: Ten adolescents aged 12–18 years who were receiving chemotherapy wereinterviewed in 2007. Open-ended interviews were conducted in a quiet in-hospitalsetting. Interview data were analysed using Giorgi’s four-step procedures.Findings.: The essential structures of the coping experience were losing confidenceand rebuilding hope. Losing confidence included sub-themes of physical and psychologicalsuffering; rebuilding hope included sub-themes of thought restructuring,revaluing what I have, and envisioning hopeful images of the future. Intervieweesvacillated between moving on and giving up, depending on the strength of theirhope. A focus on rebuilding hope helped the adolescents to move on in the midst ofmany distressful events.Conclusion.: Understanding adolescents’ coping processes relative to cancer can facilitatethe establishment of a more supportive milieu. The findings can provide guidancefor instrument development on coping for adolescents with cancer and be useful inguiding intervention development to promote positive psychological adjustment.