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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/13286

    Title: Thymol Analogues with Antioxidant and L-Type Calcium Current Inhibitory Activity.
    Authors: Ai-Yu Shen;Mei-Han Huang;Li-Fang Liao;Try-Shy Wang
    Contributors: 輔英科技大學 物理治療系
    Keywords: thymol;Mannich base;antioxidant activity;calcium ion current
    Date: 2005-08-01
    Issue Date: 2011-04-11
    Abstract: Thymol is a natural product, which has antioxidant activity. 4-Morpholinomethyl-2-
    isopropyl-5-methylphenol (THMO), and 4-Pyrrolidinomethyl-2-isopropyl- 5-methylphenol (THPY) were
    synthesized by reacting thymol with formaldehyde and, respectively, morpholine or pyrrolidine. Since
    there is a relationship between the antioxidative status and incidence of human disease, antisuperoxidation,
    free radical scavenger activity, and anti-lipid peroxidation of the thymol analogues were
    determined by xanthine oxidase inhibition, cytochrome C system with superoxide anion releasing with
    formyl-Met-Leu-Phe (fMLP)/cytochalasin (CB) or phorbol myristate acetate (PMA) activating pathway in
    human neutrophils. All compounds studied had antioxidant activity. Mannich bases derived from thymol
    were generally found to be more potent compounds than thymol. THMO demonstrated the greatest
    antioxidant activity with IC50 values for xanthine oxidase inhibition and anti-lipid peroxidation being
    2172.78 and 61.2975.83 mM, respectively. Moreover, since oxidative stress by free radical regulates the
    activity of L-type Ca2þ channel, the whole-cell configuration of the patch-clamp technique was used to
    investigate the effect of THMO upon ionic currents within NG108-15 cells. THMO (10 mM) suppressed the
    peak amplitude of L-type Ca2þ inward current (ICa,L), indicating that the antioxidative potential of the
    thymol analogues might be related to calcium current inhibition. The present studies suggest that THMOdependent
    antioxidant and calcium ion current inhibition activity may be useful in treating free radicalrelated
    Relation: Drug Dev. Res. 64,195-202
    Appears in Collections:[物理治療系] 期刊論文

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