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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/13734


    Title: Exopolysaccharide activities from probiotic bifidobacterium: Immunomodulatory effects (on J774A.1 macrophages) and antimicrobial properties
    Authors: Wu, M.H.;Pan, T.M.;Wu, Y.J.;Chang, S.J.;Chang, M.S.;Hu, C.Y.
    Contributors: 輔英科技大學 保健營養系
    Keywords: Probiotics;Exopolysaccharide (EPS);Cytokine;Macrophage;Antimicrobial test
    Date: 2010-10-01
    Issue Date: 2011-08-30 22:57:50 (UTC+8)
    Abstract: Exopolysaccharides (EPSs) are a metabolite of probiotics which have gained wide interest recently, but little is known about their function. EPS was isolated from Bifidobacterium longum BCRC 14634 and sterilized by 0.22 μm filter. The proliferation of J77A.1 macrophages and their secretion of the anti-inflammatory cytokine interleukin-10 (IL-10) was elevated after treatment with heat-killed B. longum or 5 μg/mL EPS. The endotoxin, lipopolysaccharides (LPS), a potent inducer of pro-inflammatory cytokine tumor necrosis factor-α (TNF-α), significantly suppressed the growth of J77A.1 cells, and induced the secretion of TNF-α from J774A.1 cells. Furthermore, 24h pretreatment with 5 μg/ml EPS suppressed 100 ng/ml LPS-induced cell growth inhibition and release of TNF-α from J774A.1 cells. Additional experiments showed that 80 μg/mL EPS had antimicrobial activity against 7 species of food-spoilage and infection bacteria. Our results suggest that EPS from B. longum might be useful as a mild immune modulator for macrophages, contributing to the capacity of B. longum to fight against gastrointestinal infections, and even some food-spoilage microbe.
    Relation: International Journal of Food Microbiology 144(1),104-110
    Appears in Collections:[保健營養系] 期刊論文

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