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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/13745


    Title: Rubella seroepidemiology and estimations of the catch-up immunization rate and persistence of antibody titers in pregnant women in Taiwan
    Authors: Lin , C.C.;Yang, C.Y;Shih, Y.L.;Hsu, H.W.;Yang, T.H.;Cheng,Y.W.;Chang, C.F.;Hsieh , L.C.;Chen , B.H.;Lee , C.H.;Huang , Y.L.
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: Catch-up immunization;congenital rubella syndrome (CRS);rubella
    Date: 2011-05-01
    Issue Date: 2011-08-30 22:58:40 (UTC+8)
    Abstract: Objective To examine rubella seroepidemiology, and estimate
    rates of catch-up immunisation and persistence of antibody titers
    in pregnant women in Taiwan after mass immunisation.
    Design A retrospective study.
    Setting Two medical centres and four regional hospitals
    specialising in obstetric care.
    Sample A total of 43 640 prenatal rubella test results for pregnant
    women from 2001 to 2008.
    Methods Rubella immunoglobulin G (IgG) antibody assay.
    Main outcome measures Seronegativity, rate of catch-up
    immunization, and antibody decline.
    Results The seronegativity was 10.9% in all pregnant women.
    Immigrant women had higher seronegativity than indigenous
    women (OR 2.86; 95% CI 2.65, 3.01). Indigenous women born
    prior to implementation of the vaccination programmes were
    more susceptible (20.1%) to rubella infection than were women
    born thereafter (6.7%). Rates of seropositive conversion were low
    in both Taiwanese-born and foreign-born women (11.5 and
    30.7%, respectively). The rubella antibody titers for vaccinated
    Taiwanese women in the 1971–1976 and after-1976 birth cohorts
    declined by 0.6 and 2.3% per year, respectively.
    Conclusions This study demonstrates high seronegativity of older
    indigenous and immigrant women, a low catch-up immunisation
    rate, and the persistence of rubella antibodies in Taiwan after
    mass vaccination. Our study suggests that a single dose of rubella
    vaccine in teenagers effectively increased rubella seropositivity
    during their childbearing years. This finding is useful for countries
    that lack the resources necessary for a two-dose regimen. We
    recommend free rubella antibody tests to women of childbearing
    age and free vaccination as required. All postpartum women
    testing negative for rubella antibodies should be vaccinated before
    they leave hospital.
    Relation: BJOG- International Journal of Obstetrics & Gynaecology 118(6),706-712
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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