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|Title: ||Rubella seroepidemiology and estimations of the catch-up immunization rate and persistence of antibody titers in pregnant women in Taiwan|
|Authors: ||Lin , C.C.;Yang, C.Y;Shih, Y.L.;Hsu, H.W.;Yang, T.H.;Cheng,Y.W.;Chang, C.F.;Hsieh , L.C.;Chen , B.H.;Lee , C.H.;Huang , Y.L.|
|Contributors: ||輔英科技大學 醫學檢驗生物技術系|
|Keywords: ||Catch-up immunization;congenital rubella syndrome (CRS);rubella|
|Issue Date: ||2011-08-30 22:58:40 (UTC+8)|
|Abstract: ||Objective To examine rubella seroepidemiology, and estimate|
rates of catch-up immunisation and persistence of antibody titers
in pregnant women in Taiwan after mass immunisation.
Design A retrospective study.
Setting Two medical centres and four regional hospitals
specialising in obstetric care.
Sample A total of 43 640 prenatal rubella test results for pregnant
women from 2001 to 2008.
Methods Rubella immunoglobulin G (IgG) antibody assay.
Main outcome measures Seronegativity, rate of catch-up
immunization, and antibody decline.
Results The seronegativity was 10.9% in all pregnant women.
Immigrant women had higher seronegativity than indigenous
women (OR 2.86; 95% CI 2.65, 3.01). Indigenous women born
prior to implementation of the vaccination programmes were
more susceptible (20.1%) to rubella infection than were women
born thereafter (6.7%). Rates of seropositive conversion were low
in both Taiwanese-born and foreign-born women (11.5 and
30.7%, respectively). The rubella antibody titers for vaccinated
Taiwanese women in the 1971–1976 and after-1976 birth cohorts
declined by 0.6 and 2.3% per year, respectively.
Conclusions This study demonstrates high seronegativity of older
indigenous and immigrant women, a low catch-up immunisation
rate, and the persistence of rubella antibodies in Taiwan after
mass vaccination. Our study suggests that a single dose of rubella
vaccine in teenagers effectively increased rubella seropositivity
during their childbearing years. This finding is useful for countries
that lack the resources necessary for a two-dose regimen. We
recommend free rubella antibody tests to women of childbearing
age and free vaccination as required. All postpartum women
testing negative for rubella antibodies should be vaccinated before
they leave hospital.
|Relation: ||BJOG- International Journal of Obstetrics & Gynaecology 118(6),706-712|
|Appears in Collections:||[醫學檢驗生物技術系] 期刊論文|
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