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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/13791


    Title: RTX Toxin Enhances the Survival of Vibrio vulnificus During Infection by Protecting the Organism From Phagocytosis.
    Authors: Lo, H.R.;Lin, J.H.;Chen, Y.H.;Chen, C.L.;Shao, C.P.;Lai, Y.C.;Hor, L.I.
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Date: 2011-06-01
    Issue Date: 2011-08-30 22:59:08 (UTC+8)
    Abstract: Vibrio vulnificus is a marine bacterium causing serious septicemia and wound infection in humans. It produces an RTX toxin that can lyse a variety of cells and is important for virulence in mice. In this study, we explored the role of RTX in pathogenesis by characterizing an RTX-deficient mutant. This mutant showed an ∼2-log reduction in virulence for mice infected by various routes. Survival of the mutant at the infection site and subsequent spread into the bloodstream were impaired. In mice pretreated with cyclophosphamide to deplete the neutrophils, both the virulence and survival at the infection site of this mutant were enhanced. This mutant was further shown to be more readily cleared from the macrophage-rich mouse peritoneal cavity and phagocytosed by murine macrophages. These findings suggest that the RTX of V. vulnificus is required for bacterial survival during infection by protecting the organism from phagocytosis.
    Relation: Journal of Infectious Diseases 203(12),1866-1874
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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