Fooyin University Institutional Repository:Item 987654321/13794
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    题名: Human herpesvirus 8 viral FLICE-inhibitory protein retards cell proliferation via downregulation of Id2 and Id3 expression.
    作者: Wang ,Yi-Fen;Wang, Lin-Yu;Li, Yi-Ling;Shyu, Huey-Wen;Chiou, Yee-Hsuan;Chou, Miao-Chen;Lin, Kuan-Hua;Tai, Ming-Hong;Chen, Chang-Yu
    贡献者: 輔英科技大學 醫學檢驗生物技術系
    关键词: Viral FLIP;Id2;Id3;Cell cycle;Proliferation;HHV8
    日期: 2010-10-01
    上传时间: 2011-08-30 22:59:10 (UTC+8)
    摘要: Death receptor-mediated apoptosis is potently inhibited by viral FLIP (FLICE/caspase 8 inhibitory protein) through reduced activation of procaspase 8. In this study, we show that the human herpesvirus 8-encoded vFLIP retards cell proliferation. Overexpression of vFLIP caused cell cycle arrest, with an apparent decrease of cells in the S phase. The Id (inhibitor of DNA binding) proteins are considered as dominant negative regulators of differentiation pathways, but positive regulators of cellular proliferation. The mechanisms by which Id proteins promote the cell cycle are diverse, but appear to involve affecting the expression of cell cycle regulators. RT-PCR results demonstrated that the expression of vFLIP decreased the expression levels of Id2 and Id3 as well as cyclin E and cyclin A compared with the vFLIP-null cells. These indicate that vFLIP affects cell proliferation by decreasing the expression levels of cell cycle regulatory proteins.
    關聯: Molecular and Cellular Biochemistry 343(1-2),83-89
    显示于类别:[醫學檢驗生物技術系] 期刊論文

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