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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/14421


    Title: Ultraviolet C Irradiation Induces Different Expression of Cyclooxygenase 2 in NIH 3T3 Cells and A431 Cells: The Roles of COX-2 Are Different in Various Cell Lines
    Authors: Ming-Hong Tai;Chien-Hui Weng;Dir-Pu Mon;Chun-Yi Hu;Ming-Hsiu Wu
    Contributors: 輔英科技大學 保健營養系
    Keywords: ultraviolet C (UVC), cyclooxygenases-2 (COX-2), prostaglandin E2 (PGE2), NIH 3T3 cells, A431 cells
    Date: 2012-04-01
    Issue Date: 2012-09-03 16:28:04 (UTC+8)
    Abstract: Ultraviolet C (UVC) is a DNA damage inducer, and 20 J/m(2) of UVC irradiation caused cell growth inhibition and induced cell death after exposure for 24-36 h. The growth of NIH 3T3 cells was significantly suppressed at 24 h after UVC irradiation whereas the proliferation of A431 cells was inhibited until 36 h after UVC irradiation. UVC irradiation increased COX-2 expression and such up-regulation reached a maximum during 3-6 h in NIH 3T3 cells. In contrast, UVC-induced COX-2 reached a maximum after 24-36 h in A431 cells. Measuring prostaglandin E2 (PGE2) level showed a biphasic profile that PGE2 release was rapidly elevated in 1-12 h after UVC irradiation and increased again at 24 h in both cell lines. Treatment with the selective COX-2 inhibitor, SC-791, during maximum expression of COX-2 induction, attenuated the UVC induced-growth inhibition in NIH 3T3 cells. In contrast, SC-791 treatment after UVC irradiation enhanced death of A431 cells. These data showed that the patterns of UVC-induced PGE2 secretion from NIH 3T3 cells and A431 cells were similar despite the differential profile in UVC-induced COX-2 up-regulation. Besides, COX-2 might play different roles in cellular response to UVC irradiation in various cell lines.
    Relation: International Journal of Molecular Science 13(4), 4351-4366 (impact factor= 2.279, Ranking= 41/147 ) 13(4),4351-4366
    Appears in Collections:[保健營養系] 期刊論文

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