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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/14450


    Title: Cisplatin Disrupts the Latency of Human Herpesvirus 8 and Induces Apoptosis in Primary Effusion Lymphoma Cells.
    Authors: Yi-Fen Wang;Yee-Hsuan Chiou;Lin-Yu Wang;Su-Ting Chang;Huey-Wen Shyu;Chang-Yu Chen;Kuan-Hua Lin;Miao-Chen Chou
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: Cisplatin, Primary effusion lymphoma, LANA, vFLIP, p53
    Date: 2012-05-01
    Issue Date: 2012-09-03 16:30:11 (UTC+8)
    Abstract: Human herpesvirus 8 (HHV8) is the etiologic agent for primary effusion lymphoma (PEL). The aim of this study is to investigate the effects of cisplatin on the PEL cells. Cisplatin treatment induced apoptosis and inhibited the growth of PEL cells, and the effect was more profound in the HHV8-positive lymphoma cells compared with the EBV-positive lymphoma cells. Cisplatin treatment decreased the expression of HHV8 latent genes and activated p53 at serine 15 in PEL cells. Our results indicate that cisplatin can disrupt HHV8 latency and induce reactivation of p53 and highly selective treatment modality for this virally induced lymphoma.
    Relation: Cancer Investigation 30(4),268-274
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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