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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/14506


    Title: 10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer
    Authors: Chung-Yi Chen , Kuo-Chen Cheng, Andy Y Chang, Ying-Ting Lin , You-Cheng Hseu and Hui-Min Wang
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: ginger;10-shogaol;antioxidant activities;skin cell;proliferation;growth factors;migration
    Date: 2012-02-01
    Issue Date: 2012-09-20 14:21:43 (UTC+8)
    Abstract: In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
    Relation: International Journal of Molecular Sciences 13(2),1762-1777
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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