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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/14963

    Title: Reliable categorisation of visual scoring of coronary artery calcification on low-dose CT for lung cancer screening: validation with the standard Agatston score
    Authors: Yi-Luan Huang;Fu-Zong Wu;Yen-Chi Wang;Yu-Jeng Ju;Guang-Yuan Mar;Chiung-Chen Chuo;Huey-Shyan Lin;Ming-Ting Wu
    Contributors: 輔英科技大學 健康事業管理學位學程
    Keywords: Computed tomography;Coronary arteriosclerosis;Rating scale Screening;Validation studies
    Date: 2013-05-01
    Issue Date: 2013-08-19 11:05:21 (UTC+8)
    Abstract: Objectives: To validate the reliability of the visual coronary artery calcification score (VCACS) on low-dose CT (LDCT) for concurrent screening of CAC and lung cancer. Methods: We enrolled 401 subjects receiving LDCT for lung cancer screening and ECG-gated CT for the Agatston score (AS). LDCT was reconstructed with 3- and 5-mm slice thickness (LDCT-3mm and LDCT-5mm respectively) for VCACS to obtain VCACS-3mm and VCACS-5mm respectively. After a training session comprising 32 cases, two observers performed four-scale VCACS (absent, mild, moderate, severe) of 369 data sets independently, the results were compared with four-scale AS (0, 1-100, 101-400, >400). Results: CACs were present in 39.6 % (146/369) of subjects. The sensitivity of VCACS-3mm was higher than for VCACS-5mm (83.6 % versus 74.0 %). The median of AS of the 24 false-negative cases in VCACS-3mm was 2.3 (range 1.1–21.1). The false-negative rate for detecting AS ? 10 on LDCT-3mm was 1.9 %. VCACS-3mm had higher concordance with AS than VCACS-5mm (k?=0.813 versus k?=?0.685). An extended test of VCACS-3mm for four junior observers showed high inter-observer reliability (intra-class correlation?=?0.90) and good concordance with AS (k?=?0.662–0.747). Conclusions: This study validated the reliability of VCACS on LDCT for lung cancer screening and showed that LDCT-3mm was more feasible than LDCT-5mm for CAD risk stratification.
    Relation: European Radiology 23(5),1226-1233
    Appears in Collections:[健康事業管理系] 期刊論文

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