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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/15332

    Title: 5-Episinuleptolide Acetate, a Norcembranoidal Diterpene from the Formosan Soft Coral Sinularia sp., Induces Leukemia Cell Apoptosis through Hsp90 Inhibition.
    Authors: Kao-Jean Huang;Yu-Cheng Chen;Mohamed El-Shazly;Ying-Chi Du;Jui-Hsin Su;Chia-Wei Tsao;Wei-Hsuan Yen;Wen-Been Chang;Yin-Di Su;Yao-Tsung Yeh;Mei-Chin Lu
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: 5-episinuleptolide acetate;apoptosis;soft coral;Hsp90;mitochondria;ROS;Sinularia sp
    Date: 2013-03-01
    Issue Date: 2013-08-28 15:04:02 (UTC+8)
    Abstract: 5-Episinuleptolide acetate (5EPA), a cytotoxic norcembranoidal diterpene recently identified from the Formosan soft coral Sinularia sp., exhibited potent activity against the K562, Molt 4 and HL 60 cancer cell lines. The antiproliferative assay, as well as the annexin V-FITC/propidium iodide (PI) apoptotic assay, indicated that the HL 60 cell line is the most sensitive one towards 5EPA. This diterpenoid led to caspases -3, -8, and -9 activation as well as PARP cleavage. It also induced ROS generation, calcium accumulation and disruption of mitochondrial membrane potential. Additionally, the expression levels of Hsp90 protein and several client proteins were downregulated in response to 5EPA treatment. These results suggest that 5EPA's cytotoxic effect on HL 60 cells may be attributed to the inhibition of Hsp90 as well as the induction of mitochondrial stress which finally results in apoptotic cell death.
    Relation: Molecules 18(3),2924-2933
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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