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|Title: ||Clinical characteristics, hospital outcome and prognostic factors of patients with ventilator-related pneumothorax|
|Authors: ||Hsu, CW;Sun, SF;Lee, DL;Chu, KA;Lin, HS|
|Contributors: ||輔英科技大學 健康事業管理系|
|Keywords: ||Barotrauma;Critical care;Respiration;Pneumothorax;Prognosis|
|Issue Date: ||2014-08-11 10:44:56 (UTC+8)|
|Abstract: ||Background. Mechanical ventilation is a common cause of iatrogenic pneumothorax in intensive care units (ICU). Most of the patients with ventilator-related pneumothorax (VRP) have underlying lung diseases and is associated with increased morbidity and mortality. The prognostic factors of VRP are not clear. The objective of this study was to find the possible prognostic factors.Methods. Analysis of retrospectively collected data of patients with pneumothorax induced by mechanical ventilation. Data were obtained concerning demographics, acute physiology and chronic health evaluation (APACHE) II score, organ failure, underlying diseases, interval between the start of mechanical ventilation and pneumothorax, arterial blood gas, respiratory parameters and patient outcomes.Results. One hundred and twenty-four patients with VRP were included for analysis. The incidence rate of VRP was 0.4% (124/31,660), and the mortality rate was 77.4%. The patients with VRP had higher hospital mortality rate than that of mechanically ventilated patients without pneumothorax (77.4% vs. 13.7%, P<0.001) or patient with procedure-related pneumothorax (77.4% vs. 29.4%, P<0.001). Most cases of VRP occurred in the early phase of mechanical ventilation, and 8.9% of the patients had a later episode of pneumothorax on the opposite lung. The interval between two episodes of VRP was short, at a median time of 2 days. Cox regression analysis showed that tension pneumothorax (P=0.001), PaO2/FiO(2)<200 (P=0.002), and APACHE II score (P=0.008) were significantly associated with death.Conclusion. VRP patients with tension pneumothorax or PaO2/FiO(2)<200 had a higher risk of death. APACHE II scores were associated with mortality in the VRP patients with PaO2/FiO(2)>= 200 mmHg.|
|Relation: ||Minerva Anestesiologica 80(1), 29-38|
|Appears in Collections:||[健康事業管理系] 期刊論文|
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