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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/15786


    Title: Identification of the high molecular weight isoform of phostensin
    Authors: Yu-Shan Lin;Hsien-Lu Huang;Wei-Ting Liu;Ta-Hsien Lin;Hsien-Bin Huang
    Contributors: 輔英科技大學 保健營養系
    Keywords: phostensin-α;phostensin-β;KIAA1949;protein phosphatase-1;actin-binding protein
    Date: 2014-01-01
    Issue Date: 2014-08-14 16:33:12 (UTC+8)
    Abstract: Phostensin is encoded by KIAA1949. 5′-RACEanalysis has been used to identify the translation start site of phostensin mRNA, indicating that it encodes 165 amino acids with an apparent molecular weight of 26 kDa on SDS-PAGE. This low-molecular-weight phostensin is present in human peripheral blood mononuclear cells and many leukemic cell lines. Phostensin is a protein phosphatase-1(PP1) binding protein. It also contains one actin-binding motif at its C-terminal region and binds to the pointed ends of actin filaments, modulating actin dynamics. In the current study, a high-molecular-weight phostensin is identified by using immunoprecipitationin combination with a proteomic approach. This new species of phostensin is also encoded by KIAA1949 and consists of 613 amino acids with an apparent molecular weight of 110 kDa on SDS-PAGE. The low-molecular-weight and high-molecular-weight phostensins were named as phostensin-α and phostensin-β, respectively. Although phostensin-α is the C-terminal region of phostensin-β, it is not degraded from phostensin-β. Phostensin-β is capable of associating with PP1 and actin filaments, and is present in many cell lines.
    Relation: Int J Mol Sci. 15(1),1068-1079
    Appears in Collections:[保健營養系] 期刊論文

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