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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/16346


    Title: Separation and Determination of Cold Medicine Ingredients by Capillary ZoneElectrophoresis Using Sulfated β--Cyclodextrin as an Electrolyte Modifier and Chiral Selector
    Authors: Liu, Yu-Chih;Chang, Shu-Wen;Chen, Chih-Yu;Chien, I-Chin;Lin, Chen-Hsing
    Contributors: 輔英科技大學 應用化學及材料科學系
    Keywords: Enantioseparation;Cold medicine ingredient;Capillary zone electrophoresis;Sulfated β-cyclodextrin
    Date: 2015-02-01
    Issue Date: 2015-08-20 15:27:49 (UTC+8)
    Abstract: Capillary zone electrophoretic separations of cold medicine ingredients, including acetaminophen (AC), dextromethorphan (DMF) and racemates of phenylpropanolamine (PPA) and chlorpheniramine maleate (CPM) using randomly sulfated-β-CD (S-β-CD) as an electrolyte modifier and a chiral selector were investigated. The results indicate that S-β-CD is an excellent chiral selector and a suitable electrolyte modifier as well for the separation of those cold medicine ingredients. Influences of S-β-CD concentration and buffer concentration on the separation were examined. Baseline separation of these cold medicine ingredients with 1.0?% (w/v) S-β-CD could be simultaneously and successfully achieved within 11.8 minutes. In addition, S-β-CD could also act as a chiral selector for enantioseparation of PPA and CPM. A high enantioselectivity was obtained for these two analytes. Linear relationships between the peak area and its concentration for the calibration curves of AC and DMF were obtained (correlation coefficients: 0.9987 for AC, 0.9965 for DMF, respectively). The relative standard deviations of the migration time and peak area of AC and DMF were 0.19, 2.44?% and 0.34, 2.99?%, respectively. Detection limits were 0.93 and 2.57?μg/mL for AC and DMF, respectively. Recoveries of AC and DMF ranging between 102.42 and 97.28?% were observed. The proposed method was successfully applied to the determination of AC and DMF in cold medicines.
    Relation: Journal of the Chinese Chemical Society 62(2),191-196
    Appears in Collections:[應用化學及材料科學系] 期刊論文

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