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    Title: 6-Dehydrogingerdione restrained lipopolysaccharide-induced inflammation responses in macrophages
    Authors: Shih-Han Huang;Chien-Hsing Lee;Hui-Min Wang;Yu-Wei Chang;Chun-Yu Lin;Chen, Chung-Yi;Yen-Hsu Chen
    Contributors: 輔英科技大學 保健營養系
    Keywords: 6-dehydrogingerdione;lipopolysaccharides;inflammation;signal transducers and activators of transcription 1 and 3 (STAT-1 and -3)
    Date: 2014-09-01
    Issue Date: 2015-08-24 20:15:24 (UTC+8)
    Abstract: 6-Dehydrogingerdione (6-DG), one important component of ginger, has been reported to possess some medical effects, such as antitumor and antiatherosclerosis. Herein, the anti-inflammatory effects of 6-DG against lipopolysaccharides (LPS) induced pro-inflammation mediators in RAW 264.7 cells were investigated. Results show that 6-DG significantly attenuated inducible nitric oxide synthase (iNOS, NOS2), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) in the LPS-mediated murine macrophages (RAW 264.7 cells). 6-DG inhibited LPS-induced phosphorylation of both p38 and nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor-α (IκBα), which further prevented p-p65 nuclear factor-κB (NF-κB-p65) translocation to the nucleus. Moreover, 6-DG increased the ratio of phosphorylated signal transducers and activators of transcription 1 (p-STAT1)/p-STAT3 and down-regulated the gene expression of IL-1β, IL-6, and IL-10.
    Relation: Journal of Agricultural and Food Chemistry 62(37),9171-9179
    Appears in Collections:[Department of Nutrition and Health Science] Journal Article

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