Fooyin University Institutional Repository:Item 987654321/16423
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 6024/14565 (41%)
造访人次 : 13722354      在线人数 : 303
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻
    主页登入上传说明关于FYIR管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.fy.edu.tw:8080/ir/handle/987654321/16423


    题名: 6-Dehydrogingerdione restrained lipopolysaccharide-induced inflammation responses in macrophages
    作者: Shih-Han Huang;Chien-Hsing Lee;Hui-Min Wang;Yu-Wei Chang;Chun-Yu Lin;Chen, Chung-Yi;Yen-Hsu Chen
    贡献者: 輔英科技大學 保健營養系
    关键词: 6-dehydrogingerdione;lipopolysaccharides;inflammation;signal transducers and activators of transcription 1 and 3 (STAT-1 and -3)
    日期: 2014-09-01
    上传时间: 2015-08-24 20:15:24 (UTC+8)
    摘要: 6-Dehydrogingerdione (6-DG), one important component of ginger, has been reported to possess some medical effects, such as antitumor and antiatherosclerosis. Herein, the anti-inflammatory effects of 6-DG against lipopolysaccharides (LPS) induced pro-inflammation mediators in RAW 264.7 cells were investigated. Results show that 6-DG significantly attenuated inducible nitric oxide synthase (iNOS, NOS2), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) in the LPS-mediated murine macrophages (RAW 264.7 cells). 6-DG inhibited LPS-induced phosphorylation of both p38 and nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor-α (IκBα), which further prevented p-p65 nuclear factor-κB (NF-κB-p65) translocation to the nucleus. Moreover, 6-DG increased the ratio of phosphorylated signal transducers and activators of transcription 1 (p-STAT1)/p-STAT3 and down-regulated the gene expression of IL-1β, IL-6, and IL-10.
    關聯: Journal of Agricultural and Food Chemistry 62(37),9171-9179
    显示于类别:[保健營養系] 期刊論文

    文件中的档案:

    档案 大小格式浏览次数
    index.html0KbHTML718检视/开启


    在FYIR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    本網站典藏內容為學術研究目的之提供,請尊重著作權人之權益合理使用,請勿任意重製、轉貼、改作及散佈。

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈