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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/16428

    Title: Biofunctional constituents from Michelia compressa var. lanyuensis with anti-melanogenic properties
    Authors: Chia-Wei Chu;Chi-Ming Liu;Mei-Ing Chung;Chen, Chung-Yi
    Contributors: 輔英科技大學 保健營養系
    Keywords: Michelia compressa var. lanyuensis;Magnoliaceae;tyrosinase activity;melanin
    Date: 2015-07-01
    Issue Date: 2015-08-24 20:15:35 (UTC+8)
    Abstract: Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (?)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (?)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (?)-bornesitol and β-sitostenone displayed cytotoxicity at high concentration (100 μM), but liriodenine (5 μM), (?)-N-acetylanonaine (10 μM), and β-sitostenone (5 μM) inhibit tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening.
    Relation: Molecules 20(7),12166-12174
    Appears in Collections:[保健營養系] 期刊論文

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