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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/19164

    Title: Aqueous Ocimum gratissimum extract induces cell apoptosis in human hepatocellular carcinoma cells
    Authors: Huang, Chen-Cheng;Hwang, Jin-Ming;Tsai, Jen-Hsiang;Chen, Jing Huei;Lin, Ho;Lin, Geng-Jhih;Yang, Hsin-Ling;Liu, Jer-Yuh;Yang, Chiou-Ying;Ye, Je-Chiuan
    Contributors: 輔英科技大學 物理治療系
    Keywords: Ocimum gratissimum, hepatocellular carcinoma, cell cycle arrest
    Date: 2020-01-01
    Issue Date: 2020-09-14
    Abstract: Treatment of advanced hepatocellular carcinoma (HCC) has exhibited a poor overall survival rate of only six to ten months, and the urgency of the development of more effective novel agents is ever present. In this line of research, we aimed to investigate the effects and inhibitive mechanisms of aqueous Ocimum gratissimum leaf extract (OGE), the extract of Ocimum gratissimum, which is commonly used as a therapeutic herb for its numerous pharmacological properties, on malignant HCC cells. Our results showed that OGE decreased the cell viability of HCC SK-Hep1 and HA22T cells in a dose-dependent manner (from 400 to 800 ?g/mL), while there is little effect on Chang liver cells. Moreover, cell-cycle analysis shows increased Sub-G1 cell count in SK-Hep1 and HA22T cells which is not observed in Chang liver cells. These findings raise suspicion that the OGE-induced cell death may be mediated through proteins that regulate cell cycle and apoptosis in SK-Hep1 and HA22T cells, and further experimentation revealed that OGE treatment resulted in a dose-dependent decrease in caspase 3 and PARP expressions and in CDK4and p-ERK1/2expressions. Moreover, animal tests also exhibited decreased HCC tumor growth by OGE treatment. We therefore suggest that the inhibition of cell viability and tumor growth induced by OGE may be correlated to the alteration of apoptosis-related proteins.
    Relation: International Journal of Medical Sciences 17(3),338-346
    Appears in Collections:[物理治療系] 期刊論文

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