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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/2142


    Title: Cytotoxicity and antimicrobial activity of some naphthol derivatives.
    Authors: Ai-Yu Shen;Mei-Ing Tsai;Hua Gao;Eric J. Lien
    Contributors: 輔英科技大學 物理治療系
    Date: 1994-07-01
    Issue Date: 2010-09-26 12:13:52 (UTC+8)
    Abstract: 2-Hydroxymethyl-1-naphthol diacetate (TAC) and sixteen Mannich base derivatives of naphthol were prepared and examined for cytotoxicity and antimicrobial activity. Cytotoxicity was examined against four human carcinoma cell lines. Several derivatives were effective at concentrations < 4 micrograms/ml. TAC showed the highest cytotoxicity. Inhibition of DNA-, RNA-, and protein synthesis by TAC was also studied and discussed. TAC also exhibits potent antimicrobial activity against Enterobacter clocae 23355, Klebsiella pneumonia 13883, Proteus vulgaris 13315, Pseudomonas aeruginosa 27853, Candida parapsilosis, Candida tropicalis, Trichosposon beigelli, and Rhodotorul spp. with minimum inhibitory concentrations of 0.1-0.4 microM. These results indicate that esterification by Bruson reaction of 1-naphthol Mannich base to TAC enhances the cytotoxicity and antimicrobial activity.
    Relation: Acta. Pharm.328(2),197-201
    Appears in Collections:[物理治療系] 期刊論文

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