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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/2160

    Title: Studies on the Cardiovascular Actions of TPY-β: An Antihypertensive Agent With Antiplatelet Activity.
    Authors: Ai-Yu Shen;Che-Ming Teng;Jong-Shyan Wang.
    Contributors: 輔英科技大學 物理治療系
    Keywords: vagus nerve;nucleus tractus solitarri;antiplatelet activity;antihypertensive activity
    Date: 1999-07-01
    Issue Date: 2010-09-26 12:13:55 (UTC+8)
    Abstract: 1-Pyrrolidinylmethyl-2-naphthol hydrochloride (TPY- β) has been reported to have hypotensive and bradycardiac effects in anesthetized rats. Whether administration of atropine or bilateral vagotomy affects mean arterial pressure or heart rate was examined. The percentage difference in hypotensive and bradycardiac effect of TPY- β (0.5 mg/kg) was 63 ± 5% and 68 ± 9 %, respectively, in unpretreated rats compared to control levels. Atropine pretreatment (0.1 mg/kg, i.v.) significantly reduced the depressant effect of TPY- β, although heart rate and mean arterial pressure remained 21 ± 3% and 31 ± 4%, respectively, as compared to control levels. Vagotomy decreased heart rate and mean arterial pressure response but moderate bradycardiac (13 ± 2%) and hypotensive (10 ± 3%) effects still remained as compared to control levels. Unilateral microinjection of 1, 3.3 and 10 nM TPY- β into the nucleus tractus solitarri elicited a dose-dependent depressor (−10 ± 2; −20 ± 3; −25 ± 3 mmHg) and bradycardiac activities (−20 ± 4; −26 ± 5; −55 ± 10 beats/min). TPY- β also relaxed the isolated rat aortic rings preconstracted with high extracellular K+ (80 mM) and Ca2+ (1.9 mM). The above findings suggest that the suppressive effects of TPY- β may involve activation of vagus nerve and a direct inhibition of Ca2+ channel. In addition, TPY- β inhibited the aggregation of washed rabbit platelets (aggregated by arachidonic acid and collagen) and adhesiveness on fibrinogen-coated surface. The results suggest that TPY- β possesses antihypertensive and antiplatelet activity.
    Relation: Life Sci. 65,1817-1828
    Appears in Collections:[物理治療系] 期刊論文

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