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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/2162


    Title: A Chelating Agent Possessing Cytotoxicity and Antimicrobial Activity: 7-Morpholinomethyl-8-hydroxyquinoline.
    Authors: Ai-Yu Shen;Chi-Pien Chen;Steve Roffler
    Contributors: 輔英科技大學 物理治療系
    Keywords: cytotoxicity;antimicrobial activity;chelate;MO-8HQ
    Date: 1999-10-01
    Issue Date: 2010-09-26 12:13:55 (UTC+8)
    Abstract: 7-Morpholinomethyl-8-hydroxyquinoline (MO-8HQ), which like 8-hydroxyquinoline (8HQ) readily forms a chelate, was synthesized and found to possess cytotoxicity and antimicrobial activity. Both 8HQ and MO-8HQ were cytotoxic to human carcinoma cell lines at micromolar concentrations. MO-8HQ also inhibited DNA synthesis of tumor cells at micromolar concentrations, suggesting that MO-8HQ might chelate metals necessary for the enzymatic catalysis of DNA biosynthesis. MO-8HQ was more active against gram positive bacteria than gram negative bacteria and its potency correlated with iron chelation. An "unsaturated" chelate with a MO-8HQ to Fe ratio of 2:1 exhibited greater antibacterial activity than MO-8HQ alone. Among the organisms tested, Micrococcus flavus was most susceptible with a MIC of 3.9 microg/ml. MO-8HQ also exhibited anti-fungal activity at 7-15 microg/ml. MO-8HQ:Fe chelate markedly increased the susceptibility of Escherichia coli to deoxycholate. Addition of Ca2+ or Mg2+ reversed the sensitivity of bacteria to deoxycholate as well as to rifampicin. It is suggested that MO-8HQ exerts its biological activity as a membrane-active agent through metal ion chelation.
    Relation: Life Sci. 64(9),813-825
    Appears in Collections:[物理治療系] 期刊論文

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