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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/2225


    Title: A New Flavone C-Glycoside And Antiplatelet And Vasorelaxing Flavones From Gentiana arisanensis.
    Authors: Chun-Nan Lin;Shih-Hsien Kuo;Mei-ing Chung
    Contributors: 輔英科技大學 保健營養系
    Date: 1997-08-01
    Issue Date: 2010-09-26 14:12:18 (UTC+8)
    Abstract: A new flavone C-glycoside, isovitexin 6‘‘-O-glucoside (1), and three known flavonoids, quercetin, isovitexin, and luteolin-7-O-β-d-glucoside, have been further isolated from the whole plant of Gentiana arisanensis Hayata. The new compound was characterized by spectral methods and chemical reactions. The antiplatelet effects of isovitexin 6‘‘-O-glucoside (1), isoorientin (2), 2 peracetate (3), isovitexin (4), luteolin 7-O-β-d-glucoside (5), luteolin (6), isoorientin 6‘‘-O-glucoside (7), and 7 peracetate (8) were studied using washed rabbit platelets. Of the compounds tested, 6 showed potent antiplatelet effects on arachidonic acid (AA)-induced platelet aggregation (IC50 = 43.5 μM). The effect of 2, 5, and 6 on the contraction of rat thoracic aorta was also studied. Compound 6 depressed markedly the contraction induced by Ca2+ (1.9 mM) in high-K+ (80 mM) medium, with an IC50 of about 156 μM and also inhibited noradrenaline (3 μM)-induced phasic and tonic contractions, with an IC50 of about 68 and 72 μM, respectively.
    Relation: Journal of Natural Products 60(8),851-853
    Appears in Collections:[保健營養系] 期刊論文

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