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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/2231


    Title: ovarian steroids regulate 24p3 expression in mouse uterus during the natural estrous cycle and the preimplantation period
    Authors: Hsien-lu Huang;S T Chu;Y H Chen
    Contributors: 輔英科技大學 保健營養系
    Date: 1999-03-01
    Issue Date: 2010-09-26 14:12:19 (UTC+8)
    Abstract: We examined 24p3 expression in the mouse uterus at
    various stages of the natural estrous cycle and during the
    preimplantation period. The level of 24p3 mRNA appeared
    intensively in proestrus and estrus, then declined
    sharply from metestrus to diestrus. Consistent with this
    observation, 24p3 protein was abundant in proestrus,
    decreased from estrus to metestrus and declined to a very
    low level in diestrus. The uterine 24p3 expression closely
    overlapped with the estradiol (E2) surge in proestrus and
    estrus but it was suppressed when progesterone (P4) rose to
    a high level during the reproductive cycle. Neither the
    protein nor its message was detected in the uteri of
    immature mice or ovariectomized adult animals. While an
    injection of P4 to these animals was unable to initiate
    uterine 24p3 expression, administration of estrogenic
    steroids to these animals markedly stimulated the gene
    expression. Treatment of these animals with E2 together
    with P4, on the other hand, did not stimulate the gene
    expression. In pregnant animals (day 1 (D1)=day of
    vaginal plug), 24p3 mRNA remained at a high level on
    D1 and D2 but dropped to an almost undetectable level on
    D3 and D4. This was accompanied by a decrease in 24p3
    protein from D1 to D2 and a decline in the protein to
    undetectable levels from D3 to D4. The staining patterns
    of both the immunohistochemical localization of 24p3
    protein and in situ hybridization for the detection of
    24p3 mRNA in the uterine sections showed that 24p3
    expression took place mainly in the luminal and glandular
    epithelial cells of the endometrium. This together with our
    previous observation that 24p3 protein is found in uterine
    luminal fluid indicates that the protein is secreted primarily
    from these cells to their respective luminal surfaces during
    proestrus and estrus.
    Relation: Journal of endocrinology 162(1),11-19
    Appears in Collections:[保健營養系] 期刊論文

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