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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/2232


    Title: Metabolites of diallyl disufide and diallyl sulfide in primary rat hepatocytes.
    Authors: L. Y. Sheen;C. C. Wu;C. -K. Lii;S. -J. Tsai
    Contributors: 輔英科技大學 保健營養系
    Keywords: garlic;diallyl disulfide;diallyl sulfide;metabolite;primary rat hepatocytes
    Date: 1999-05-01
    Issue Date: 2010-09-26 14:12:19 (UTC+8)
    Abstract: The objectives of this study were to analyse and identify the metabolites of diallyl disulfide (DADS) and diallyl sulfide (DAS) in primary rat hepatocytes prepared by collagenase perfusion. According to the results, allyl mercaptan (AM) and allyl methyl sulfide (AMS) were the metabolites of DADS. The highest amount of AMS (0.93±0.08 μg/ml at 90 min) was much less than that of AM (46.2±6.6 μg/ml at 60 min). Combined with the Purge and Trap using a gas chromatography–mass spectrometry (GC–MS) system, it is very useful to detect the trace amounts of metabolites in primary rat hepatocytes. Results also showed that AMS was a metabolite of DAS. The highest amount of AMS in the extracellular fluid of hepatocytes was 0.63±0.16 μg/ml at 30 min of incubation.
    Relation: Food and Chemical Toxicology 37(12),1139-1146
    Appears in Collections:[保健營養系] 期刊論文

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