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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/2299


    Title: Red Mold Rice Extract Represses Amyloid Beta Peptide-induced Neurotoxicity via Potent Synergism of Anti-inflammatory and Antioxidative Effect
    Authors: Chun-Lin Lee;Jyh-Jye Wang;Tzu-Ming Pan
    Contributors: 輔英科技大學 保健營養系
    Keywords: Alzheimer's disease;amyloid;Monascus;monacolin K;anti-inflammatory;antioxidative
    Date: 2008-07-01
    Issue Date: 2010-09-26 14:12:27 (UTC+8)
    Abstract: Amyloid beta-peptide (A beta), a risk of Alzheimer's disease (AD), causes cell death by inflammation and oxidative stress. Red mold rice (RMR) fermented by Monascus species is regarded as cholesterol-lowering functional food in virtue of the metabolite monacolin K identified as lovastatin. In addition, RMR is also demonstrated to express antioxidation because of multiple antioxidants. Therefore, this study focuses on the synergism of RMR against A beta neurotoxicity and compares the effect between lovastatin and RMR including monacolin K and other functional metabolites. In this study, RE 568, an ethanol extract of RMR produced by strain Monascus purpureus NTU 568, is used to protect PC12 cell against A beta 40 neurotoxicity. All tests contain the treatments with lovastatin or RE 568 including equal monacolin K levels in order to compare the effect and investigate whether other metabolites of RE 568 provide potent assistance against A beta 40 neurotoxicity. In the results, monacolin K represses A beta 40 neurotoxicity via repressing small G-protein-mediated inflammation, and other metabolites of RE 568 also exhibit potent antioxidative ability against A beta-induced oxidative stress. Importantly, stronger effects on repressing the A beta 40-induced cell death, inflammation, and oxidative stress are performed by RE 568 than that by the equal levels of lovastatin, which results from a potent synergism made up of monacolin K, antioxidants, and anti-inflammatory agents. The present study is the first report to demonstrate the potent synergistic protection of RMR against A beta 40 neurotoxicity, which would cause RMR to be developed as potential and novel functional food for the prophylaxis of AD pathogenesis.
    Relation: Appl Microbiol Biotechnol 79(5),829-841
    Appears in Collections:[保健營養系] 期刊論文

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