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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/2310

    Title: Involvement of nucleophosmin/B23 in the cellular response to curcumin
    Authors: Chien-Hui Weng;Benjamin Yat-Ming Yung;Jing-Jei Weng;Ming-Hsiu Wu
    Contributors: 輔英科技大學 保健營養系
    Keywords: Curcumin;Nucleophosmin/B23;Activator protein-1;c-Jun;c-Fos
    Date: 2010-03-01
    Issue Date: 2010-09-26 14:12:29 (UTC+8)
    Abstract: Nucleophosmin (NPM/B23) is a nucleolar phosphoprotein involved in cellular response to many different stimuli. Herein, we studied the molecular mechanism of NPM/B23 induction by curcumin, a natural AP-1 inhibitor with antitumor properties. Exposure to 5-30 muM curcumin significantly and dose-dependently increased the level of NPM/B23 in non-transformed NIH 3T3 cells but not HeLa cells and F9 cells. Besides, the transformed F9 and HeLa cells are more sensitive to curcumin-induced cell death and growth inhibition than NIH 3T3 cells. Overexpression of c-Jun, but not c-Fos, decreased approximately 40% of NPM/B23 and enhanced the sensitivity of NIH 3T3 cells to 30 muM curcumin. Furthermore, down-regulation of NPM/B23 by transfection with NPM/B23 antisense plasmid enhanced the sensitivity to curcumin-induced cell death and growth inhibition. These results indicated that NPM/B23 expression regulates cellular sensitivity to curcumin. Besides, NPM/B23 knockdown may facilitate as a novel strategy to promote the sensitivity of cancer cells to curcumin.
    Relation: The Journal of Nutritional Biochemistry
    Appears in Collections:[保健營養系] 期刊論文

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