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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/3060

    Title: Biological Study of naphthylene derivatives with antiinflammatory activities
    Authors: Huang, Mei-Han;Wu,Sheng-Nan;Wang,Jih-Pyang;Lin, Chen-Hsing;Lu,Shih-I;Liao,Li-Fang;Shen,Ai-Yu
    Contributors: 輔英科技大學 應用化學及材料科學系
    Keywords: calcium current;NG 108 cells;inflammation
    Date: 2003-12
    Issue Date: 2010-09-28 10:52:05 (UTC+8)
    Abstract: In this study, 18 synthetic naphthalene derivatives were tested for their inhibitory effects on the activation of neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristic acetate (PMA). Some of these compounds showed significant antiinflammatory activities. In general, esterification of 1-naphthalene to compound 14 (2-hydroxymethyl-1-naphthol diacetate; TAC) enhanced the antioxidant activity. Compound 15, N,N-bis(2-hydroxy-1-naphthylmethyl) amine, has moderate inhibitory activity on neutrophils stimulated with fMLP as compared to Mannich bases of naphthylene derivatives. Either substitution at 1 or 2 position, except TAC, disfavored the inhibitory effects evoked by PMA stimulation. The influence of these compounds on the release of granule enzyme lysozyme-induced by fMLP was measured. TAC had the highest potency on the inhibition of lysozyme release from rat neutrophil degranulation. The effects of TAC on ionic currents in a mouse neuroblastoma and rat glioma hybrid cell line, NG105-18, were also investigated with the aid of the whole-cell patch-clamp technique. TAC caused an inhibitory effect on voltage-dependent L-type Ca2+ current (ICa,L) with an IC50 value of 0.8 µM. The inhibitory effect of TAC on ICa,L may not be caused by its inhibition of superoxide formation. Such an effect may, also in part, affect neuronal function.
    Relation: Drug Development Research,Volume 60, Issue 4, pages 261–269
    Appears in Collections:[應用化學及材料科學系] 期刊論文

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