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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/3068


    Title: Determination of Enantiomerization Barrier of Thioridazine by Dynamic Capillary Electrophoresis Using Sulfated Cyclodextrins as Chiral Selectors
    Authors: Lin,Ching-Erh;Ko,Ting-Chang;Kuo,Chia-Ming;Trapp,Oliver;Lin, Wann-Yin;Lin,Chen-Hsing;Wu,Jong-Chang;Liu,Yu-Chih
    Contributors: 輔英科技大學 應用化學及材料科學系
    Keywords: Dynamic CE;Enantiomerization barrier;Enantioseparation;Sulfated β-CD;Thioridazine
    Date: 2009-09-01
    Issue Date: 2010-09-28 10:52:06 (UTC+8)
    Abstract: The enantiomerization of thioridazine (THD) using sulfated β-CDs (S-β-CDs) as chiral selectors in a citrate buffer at pH 3.0 was investigated by dynamic CE. The enantiomers of THD were well separated with dual CD systems consisting of S-β-CD and a neutral CD. The electropherograms featuring a plateau formation, which indicated the occurrence of the enantiomerization of THD were obtained. The unified equation implemented in the software program DCXplorer was employed to evaluate elution profiles and to determine rate constants of the enantiomerization of THD. Activation parameters were evaluated from temperature-dependent measurements between 15 and 25°C with an increment of 2°C. The enantiomerization barriers of THD in two different electrophoretic systems were determined. Comparative studies on enantioseparation of THD using S-β-CDs with different degree of substitution and positions of sulfate substituent, such as randomly sulfate-substituted β-CD, 18-sulfate-substituted β-CD and heptakis(2,3-dihydroxy-6-O-sulfo)-β-CD reveal that the interactions between chiral selectors and THD plays an important role in the enantioseparation and enantiomerization of THD.
    Relation: ELECTROPHORESIS,Special Issue: EMPHASIS ON PROTEINS AND PROTEOMICS,Volume 30, Issue 17, pages 3071–3078
    Appears in Collections:[應用化學及材料科學系] 期刊論文

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