The purpose of this study was to investigate the essence of the family stress experienced by infertile women during IVF-ET therapy. The subjects were purposely chosen from a medical center in Taipei. Sample size was determined by the saturation principle of phenomenology. After the analysis of the interview data of 10 subjects, no new themes had emerged. General family information and the health history of the subjects was collected. The interview data was collected by using tape-recording and following semi-structured interview guidelines. Colaizzi’s (1978) phenomenological approach was used to analysize the transcripts. Intercoder reliability, content validity and construct validity were examined. The family stress experience by infertile women during IVF-ET therapy focused around 7 themes: the desire to have a child, frustration at infertility, the effort expended in trying their best to have a child, the feeling of being out of control, the demand for clarification of the situation, couple togetherness, and family support. The findings not only provide knowledge of family stress experience by infertile women during IVF-ET therapy from their subjective perspective, but also suggest further directions for nursing intervention.