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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/3940

    Title: Antigenic characterization of nine wild-type Taiwanese isolates of Japanese encephalitis virus as compared with two vaccine strains.
    Authors: 廖明一;Wu,Suh-Chin;Lian,Wei-Cheng;Hsu, Li-Ching;Wu,Ying-Chang
    Contributors: 輔英科技大學 生物科技系
    Date: 1998-05
    Issue Date: 2010-10-08 10:54:44 (UTC+8)
    Abstract: The antigenic properties of nine wild-type Japanese encephalitis viruses isolated in Taiwan during 1990–1994 were investigated by comparison with two inactivated vaccine strains (Beijing-1, Nakayama-NIH). All of the nine Taiwanese isolates were found to induce higher cytopathology in Vero cells but showed similar mouse virulence as the two vaccine strains. Antigenic characterization using six E protein-specific monoclonal antibodies shows two of the nine wild-type isolates (i.e. CH1949 and CH2195) presented different antigenic properties of hemagglutination inhibition and plaque reduction neutralization. The E-protein gene nucleotide sequences of CH1949 and CH2195 were determined and compared with other published sequences of the two vaccine strains and other 19 Asian/Taiwanese isolates. Phylogenetic tree analysis indicates these two wild-type Taiwanese isolates are more distant from the two vaccine strains.
    Relation: Virus Research,Volume 55, Issue 1, Pages 83-91
    Appears in Collections:[生物科技系] 期刊論文

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