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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/3953

    Title: Bile acid composition in snake bile juice and toxicity of snake bile acids to rats
    Authors: Yeh,Yen-Hung;Wang,Dar-Yi;Liau,Ming-Yi;Wu,Ming-Ling;Deng,Jou-Fang;Noguchi,Tamao;Hwang, Deng-Fwu
    Contributors: 輔英科技大學 生物科技系
    Keywords: Bile juice;Chenodeoxycholic acid;Cholic acid;Gallbladder;Snake bile;Toxicity;Renal failure;Liver dysfunction;Kidney dysfunction
    Date: 2003-11
    Issue Date: 2010-10-08 11:32:43 (UTC+8)
    Abstract: We determined the bile acid profiles in bile juice of snake gallbladders by HPLC on a silica gel RP-18 reversed-phase column. Cholic acid and chenodeoxycholic acid were predominant components in three of four snake species. To elucidate the toxic effect of snake bile acids on rats, a synthetic bile acid mixture was prepared mimicking the bile acid composition of a snake Naja naja atra bile juice. Twenty-four male Wistar rats were divided into four groups and treated orally at 3-day intervals with saline (control group) and different doses (1–3× doses) of the bile acid mixture. After treatment, the following parameters increased: the relative ratios of liver and kidney mass to body mass, the concentrations of red blood cell, hemoglobin and hematocrit in the blood, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, plasma urea nitrogen and creatinine in the plasma, and the levels of urine urea nitrogen and creatinine in the urine. Body mass of rats and the levels of Na+, K+, Ca++ in the urine of rats were significantly decreased, especially for groups treated with 2× and 3× doses of the bile acid mixture. Examination of liver and kidney pathology also showed cell enlargement and lesion in cell integrity in treated groups, especially for groups treated with 2× and 3× bile acid mixture, indicating that short-term toxicity of snake N. naja atra bile acids was significant in rats.
    Relation: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology,Volume 136, Issue 3, November 2003, Pages 277-284
    Appears in Collections:[生物科技系] 期刊論文

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