Fooyin University Institutional Repository:Item 987654321/449
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    题名: Berberine complexes with DNA in the berberine-induced apoptosis in Human leukemic HL-60 cells
    作者: Kuo, C. L.;Chou, C. C.;Yung, B. Y. M.
    贡献者: 輔英科技大學 生物科技系
    关键词: Apoptosis;Berberine-DNA complex
    日期: 1995-01-01
    上传时间: 2010-09-15 11:40:09 (UTC+8)
    摘要: Berberine, an alkaloid initially isolated from Chinese herbal medicine exhibited the ability to induce morphological changes and internucleosomal DNA fragmentation, characteristic of apoptosis in promyelocytic leukemia HL-60 cells. Cell cycle studies showed that only about 20% of the cells underwent apoptosis at the early time (6 h) of berberine (25 μg/ml) treatment; these appeared to be cells in S phase at the time of berberine treatment. At extended time (6–48 h), cells were cell cycle arrested, the number of cells of each phase, particularly the cells of S phase decreased and much more (> 50%) of the cells appeared with DNA content less than G1. Attempts were also made to isolate possible berberine-DNA complexes from cell cultures treated with berberine (25 μg/ml; 2–24 h). Shifts of absorption maxima of berberine in the direction of longer wavelengths were observed in the isolated berberine-DNA complexes. Palmatine, an analog of berberine, which was not able to induce apoptosis, also complexed with DNA in cells treated with palmatine (25 μg/ml; 2–24 h). Our results suggest that some important cellular processes other than the intracellular DNA-interacting action of berberine may be involved in the berberine-induced apoptosis in HL-60 cells.
    關聯: Cancer Letters.93: 193-200.
    显示于类别:[生物科技系] 期刊論文

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