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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/481


    Title: Intracellular ATP is required for actinomycin D-induced apoptoic cell death in HeLa cells.
    Authors: Chou, C. C.;Lam, C. Y;Yung, B. Y. M.
    Contributors: 輔英科技大學 生物科技系
    Keywords: ATP;Apoptotic cell
    Date: 1995-12-01
    Issue Date: 2010-09-17 12:14:22 (UTC+8)
    Abstract: In the present report, we demonstrate that reduction of cellular ATP content with antimycin A blocks actinomycin D-induced apoptotic cell death in HeLa cells. Compared to cells (˜80%) treated with actinomycin D (1 μg/ml, 48 h) alone in glucose-containing medium, a much smaller percentage of cells (˜20%) treated with actinomycin D in the presence of antimycin A in glucose-free medium shows morphological characteristic of apoptosis. ATP-depleted cells with or without actinomycin D treatment, on the other hand, die necrotically. In cells under actinomycin D short exposure treatment (1 μg/ml; 1 h), apoptosis occurs when cellular ATP content is rapidly recovered after the removal of antimycin A and resupplementation of glucose-containing medium. In the incubation of isolated Triton-permeabilized cells with ATP (>0.5 mM), apoptotic nuclei become abundant 4 h after ATP treatment. These results implicate the requirement of ATP for the induction of apoptosis.
    Relation: Cancer Letters 96: 181-187.
    Appears in Collections:[生物科技系] 期刊論文

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