This case report explored the physical, psychological, and spiritual problems of a patient with oral cancer and tumor ulcer at the terminal stage. The authors assessed the patient's physical, psychological, social, and spiritual problems based on Gorden's eleven health functional patterns through physical assessment, interviews, and observation of family interactions. Four patient's problems were identified: tissue integrity, impaired; chronic pain; body image, disturbed; spiritual distress. During the nursing process, the authors assessed the wound thoroughly, offered wound care and comfort skills, and reduced the ooze and stench of the wound to reduce the patient's feeling of embarrassment and shame. In addition, the authors relieved the patient's pain through using the pharmacological and non-traditional pain-relieving strategies. The patient finally could positively accept the changes of his physical structures and functions. Furthermore, we assisted the patient to understand the truth of Buddhism and bravely face the death through involving the social worker and the religionist of the health care team into the hospice care. It is expected this case report can offer nurses in the hospice units how to apply the strength of spirituality to overcoming the patient's anxiety for death during the dying course. Nurses can help dying patients make good preparations for his own death. Both the patient and the family can face the dying process peacefully and serenely. Nursing care can achieve win-win situations.