This paper aimed to present the nursing experience of a patient with acute pulmonary edema caused by mitral valve insufficiency being weaned successfully from ventilator. Nursing assessment was based on the framework of Gordon's 11 functional evaluations. Three health problems, including decreased cardiac output, impaired gas exchange, and anxiety, were found. In order to provide good nursing care and reduce the suffering of the patient, the author taught the patient to promote the performance of the lungs through deep breathing and coughing, which is capable of exhausting co2 from the lungs and improve the condition of impaired gas exchange. During mechanical ventilation, the patient was self-extubated from the ventilatory support deliberately. After the reintubation, writing notes in communication was used for encouragement and helping the patient to express their innermost thoughts. In order to enhance the patient's confidence for successful weaning from the ventilator, the author introduced the successful case of the neighboring patient. In addition, family involvement and support was crucial to the patient's success in weaning from a ventilator in this case. Psychological and physiological nursing experience is presented to understand the nursing process of a patient weaning from ventilation for a similar case.