English  |  正體中文  |  简体中文  |  Items with full text/Total items : 6047/14565 (42%)
Visitors : 13678814      Online Users : 387
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/6624


    Title: The dynamic responses of pro-inflammatory and anti-inflammatory cytokines of mononuclear cells induced by uromodulin.
    Authors: Shu-Jem Su;Trai-Ming Yeh
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: inflammation;monocyte;lipopolysacchride;interleukin 1β;interleukin 1 receptor antagonist;soluble tumor necrosis factor receptor;tumor necrosis factor-α
    Date: 1999-11-01
    Issue Date: 2010-10-14 09:37:56 (UTC+8)
    Abstract: This study was undertaken to examine the dynamic response of human peripheral blood mononuclear cells (PBMC) in the secretion of proinflammatory and anti-inflammatory cytokines induced by uromodulin (URO). Levels of tumor necrosis factor-α (TNFα), TNF soluble receptor (sTNFRI and II), interleukin 1-β (IL-1β), and IL-1 receptor antagonist (IL-1Ra) in the supernatants of URO-stimulated PBMC were measured by ELISA. URO stimulated the secretion of all these cytokines in a dose dependent manner except sTNFRI. Peak levels of TNFα and IL-1β were reached at 6–12 h, while 5–10 fold higher in sTNFR II and IL-1Ra levels were observed at 24–48 h after URO stimulation. URO-induced secretion of TNFα, IL-1β, sTNFRII and IL-1Ra could be enhanced by human plasma. Specifically, serum proteins including C3, sCD14 and IgG not only bound to URO but also enhanced URO-induced TNFα secretion of PBMC. Collectively, our data suggest that URO might have dual immunomodulating effect through regulating the secretion of proinflammatory and anti-inflammatory cytokines, and that serum binding proteins might enhance this activity.
    Relation: Life Science 65(24),2581-2590
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML1030View/Open


    All items in FYIR are protected by copyright, with all rights reserved.


    本網站典藏內容為學術研究目的之提供,請尊重著作權人之權益合理使用,請勿任意重製、轉貼、改作及散佈。

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback