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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/6627

    Title: Dorsal facial area of cat medulla: 5-HT2 action on glutamate release in regulating common carotid blood flow
    Authors: Jon-Son Kuo;Hsing-Tan Li;Nai-Nu Lin;Chung-Shi Yang;Fu-Chou Cheng
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: Neurotransmitter;Excitatory amino acids;Cerebral circulation
    Date: 1999-09-01
    Issue Date: 2010-10-14 09:39:59 (UTC+8)
    Abstract: Serotonin (5-HT) may inhibit glutamate release in the dorsal facial area (DFA) of the medulla and decrease common carotid arterial (CCA) blood flow. We attempted to clarify which subtype(s) of 5-HT receptor was involved. A microdialysis probe was inserted in DFA. The concentration of glutamate in dialysates were determined by chromatography. Glutamate concentration was dose-dependently decreased by perfusion of 5-HT or DOI, a 5-HT2 agonist, but not by 5-CT, a 5-HT1 agonist. The 5-HT-induced decrease in glutamate was reversed by co-perfusion of ketanserin, a 5-HT2 antagonist, but not by propranolol, a 5-HT1 antagonist. CCA blood flow was decreased when 5-HT or DOI was perfused, and was reversed by co-perfusing ketanserin. In conclusion, 5-HT may inhibit glutamate release via 5-HT2 receptor in DFA, resulting in the reduction of CCA blood flow.
    Relation: Neuroscience Letters 266(2),137-140
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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