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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/7112


    Title: Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway.
    Authors: Shyng-Shiou F. Yuan;Hsueh-Ling Chang;Hsiao-Wen Chen;Yao-Tsung Yeh;Ying-Hsien Kao;Kuei-Hsiang Lin;Yang-Chang Wu;Jinu-Huang Su
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: Annonaceae;Annona reticulata;Acetogenins;Annonacin;Cytotoxicity;Apoptosis;Cell cycle checkpoints
    Date: 2003-05-01
    Issue Date: 2010-10-15 16:05:33 (UTC+8)
    Abstract: Annonaceous acetogenins are a group of potential anti-neoplastic agents isolated from Annonaceae plants. In this study, we purified annonacin, a cytotoxic mono-tetrahydrofuran acetogenin, from the seeds of Annona reticulata and analyzed its biological effects. Herein, we have shown that annonacin caused significant cell death in various cancer cell lines. T24 bladder cancer cells at the S phase were more vulnerable to the cytotoxicity of annonacin. Furthermore, annonacin activated p21 in a p53-independent manner and arrested T24 cells at the G1 phase. It also induced Bax expression, enhanced caspase-3 activity, and caused apoptotic cell death in T24 cells. In summary, these results suggest that annonacin is potentially a promising anti-cancer compound.
    Relation: Life Sci 72(25),2853-2861
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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