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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/7147

    Title: Biological study of naphthalene derivatives with antiinflammatory activities.
    Authors: Mei-Han Huang;Sheng-Nan Wu;Jih-Pyang Wang;Chen-Hsing Lin;Shih-I Lu;Li-Fang Liao;Ai-Yu Shen
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: calcium current;NG 108 cells;inflammation
    Date: 2003-12-01
    Issue Date: 2010-10-18 12:18:19 (UTC+8)
    Abstract: In this study, 18 synthetic naphthalene derivatives were tested for their inhibitory effects
    on the activation of neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or
    phorbol myristic acetate (PMA). Some of these compounds showed significant antiinflammatory activities.
    In general, esterification of 1-naphthalene to compound 14 (2-hydroxymethyl-1-naphthol diacetate; TAC)
    enhanced the antioxidant activity. Compound 15, N,N-bis(2-hydroxy-1-naphthylmethyl) amine, has
    moderate inhibitory activity on neutrophils stimulated with fMLP as compared to Mannich bases of
    naphthylene derivatives. Either substitution at 1 or 2 position, except TAC, disfavored the inhibitory effects
    evoked by PMA stimulation. The influence of these compounds on the release of granule enzyme
    lysozyme-induced by fMLP was measured. TAC had the highest potency on the inhibition of lysozyme
    release from rat neutrophil degranulation. The effects of TAC on ionic currents in a mouse neuroblastoma
    and rat glioma hybrid cell line, NG105-18, were also investigated with the aid of the whole-cell patchclamp
    technique. TAC caused an inhibitory effect on voltage-dependent L-type Ca2� current (ICa,L) with an
    IC50 value of 0.8 mM. The inhibitory effect of TAC on ICa,L may not be caused by its inhibition of
    superoxide formation. Such an effect may, also in part, affect neuronal function.
    Relation: DRUG DEVELOPMENT RESEARCH 60(4),261-269
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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