English  |  正體中文  |  简体中文  |  Items with full text/Total items : 6024/14565 (41%)
Visitors : 13702303      Online Users : 267
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/7147


    Title: Biological study of naphthalene derivatives with antiinflammatory activities.
    Authors: Mei-Han Huang;Sheng-Nan Wu;Jih-Pyang Wang;Chen-Hsing Lin;Shih-I Lu;Li-Fang Liao;Ai-Yu Shen
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: calcium current;NG 108 cells;inflammation
    Date: 2003-12-01
    Issue Date: 2010-10-18 12:18:19 (UTC+8)
    Abstract: In this study, 18 synthetic naphthalene derivatives were tested for their inhibitory effects
    on the activation of neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or
    phorbol myristic acetate (PMA). Some of these compounds showed significant antiinflammatory activities.
    In general, esterification of 1-naphthalene to compound 14 (2-hydroxymethyl-1-naphthol diacetate; TAC)
    enhanced the antioxidant activity. Compound 15, N,N-bis(2-hydroxy-1-naphthylmethyl) amine, has
    moderate inhibitory activity on neutrophils stimulated with fMLP as compared to Mannich bases of
    naphthylene derivatives. Either substitution at 1 or 2 position, except TAC, disfavored the inhibitory effects
    evoked by PMA stimulation. The influence of these compounds on the release of granule enzyme
    lysozyme-induced by fMLP was measured. TAC had the highest potency on the inhibition of lysozyme
    release from rat neutrophil degranulation. The effects of TAC on ionic currents in a mouse neuroblastoma
    and rat glioma hybrid cell line, NG105-18, were also investigated with the aid of the whole-cell patchclamp
    technique. TAC caused an inhibitory effect on voltage-dependent L-type Ca2� current (ICa,L) with an
    IC50 value of 0.8 mM. The inhibitory effect of TAC on ICa,L may not be caused by its inhibition of
    superoxide formation. Such an effect may, also in part, affect neuronal function.
    Relation: DRUG DEVELOPMENT RESEARCH 60(4),261-269
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML1069View/Open


    All items in FYIR are protected by copyright, with all rights reserved.


    本網站典藏內容為學術研究目的之提供,請尊重著作權人之權益合理使用,請勿任意重製、轉貼、改作及散佈。

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback