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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/7150

    Title: Aberrant expression and possible involvement of the leptin receptor in endometrial cancer.
    Authors: Shyng-Shiou F Yuan;Kun-Bow Tsai;Yueh-Fang Chung;Te-Fu Chan;Yao-Tsung Yeh;Li-Yu Tsai;Jinu-Huang Su
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: Leptin;Leptin receptor;Endometrial cancer;Differentiation
    Date: 2004-02-01
    Issue Date: 2010-10-18 12:18:20 (UTC+8)
    Abstract: Objective. Leptin and its receptor are the key players in the regulation of energy balance and body weight control. However, their roles in gynecological malignancies are mostly unclear. In this study, we analyzed the expression and possible involvement of leptin and the leptin receptor in the pathogenesis of endometrial cancer.

    Methods. Radioimmunoassay was performed to analyze the serum leptin levels in the endometrial cancer patients, while RT-PCR, immunoblotting, and immunohistochemistry techniques were applied to study the expression of leptin receptor in the endometrioid-type endometrial cancer tissues. Furthermore, BrdU labeling followed by immunofluorescent analysis was used to analyze the effect of leptin receptor overexpression on endometrial cancer cell proliferation.

    Results. Serum leptin levels are elevated in endometrial cancer patients, but show no significant difference to those of normal controls when normalized by body mass index. On the other hand, lower expression levels of leptin receptor short form (Ob-Ra) were observed in most endometrial cancer tissues, especially in the poorly differentiated ones, and the forced expression of Ob-Ra in RL95-2 endometrial cancer cells prevented them from entering the S-phase.

    Conclusion. In summary, our data demonstrates for the first time that the leptin receptor is aberrantly expressed in endometrial cancer tissues and is possibly involved in the pathogenesis of endometrial cancer.
    Relation: Gynecol Oncol 92(3),769-775
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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