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    Title: Annoglabayin, a Novel Dimeric Kaurane Diterpenoid and Apoptosis on Hep G2 cells of Annomontacin from the Fruits of Annona glabra
    Authors: Ching-Hsein Chen;Tian-Jye Hsieh;Tsan-Zon Liu;Chi-Liang Chern;Pei-Ying Hsieh;Chung-Yi, Chen
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Date: 2004-11-01
    Issue Date: 2010-10-21 11:42:24 (UTC+8)
    Abstract: Annoglabayin (1), a novel Annona dimeric kaurane diterpenoid, has been isolated from Annona glabra, and its structure was determined on the basis of spectroscopic analysis. Annoglabayin (1) contains a unique carbon bridge between two nor-ent-kaurane monomeric units. The dose−response of 2 in Hep G2 cells indicated that 2 increased DNA damage. In addition, our results showed that 2 induced a noticeable decrease in mitochondrial transmembrane potential during treatment. These results indicate that 2 produces apoptotic events in Hep G2 cells, through inducing changes in mitochondria.
    Relation: Journal of Natural Products 67(11),1942-1946
    Appears in Collections:[Department of Medical Technology] Journal Article

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