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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/8283

    Title: Liriodenine inhibits the proliferation of human hepatoma cell lines by blocking cell cycle progression and nitric oxide-mediated activation of p53 expression.
    Authors: Tian-Jye Hsieh;Tsan-Zon Liu;Chi-Liang Chen;Der-An Tsao;Fung-Jou Lu;Yu-Hua Syu;Pei-Ying Hsieh;Han-Shu Hu;Ting-Ting Chang;Ching-Hsein Chen
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: Liriodenine;Cell cycle;Nitric oxide;iNOS;p53
    Date: 2005-07-01
    Issue Date: 2010-10-26 15:02:40 (UTC+8)
    Abstract: Liriodenine was isolated from the leaves of Michelia compressa. This study was designed to assess cell cycle arrest, the production of nitric oxide (NO) and p53 expression in liriodenine-treated human hepatoma cell lines, including wild-type p53 (Hep G2 and SK-Hep-1). As evidenced by flowcytometric studies, liriodenine induced cell cycle G1 arrest and inhibited DNA synthesis in Hep G2 and SK-Hep-1 cell lines. The p53, iNOS expression and intracellular NO level were markedly increased in Hep G2 cells after liriodenine treatment. A NO inhibitor, carboxy-PTIO inhibited the p53 expression induced by liriodenine. In addition, liriodenine could not induce obvious cytotoxicity in normal human IMR-90 cell line. These results demonstrate that NO production and p53 expression are critical factors in liriodenine-induced growth inhibition in human wild-type p53 hepatoma cells.
    Relation: Food Chem Toxicol 43(7),1117-1126
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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