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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/8293


    Title: Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Amphetamine, Methamphetamine, 3,4-Methylenedioxyamphetamine and 3,4-Methylenedioxymethamphetamine in Human Hair and Hair Sections.
    Authors: Dong-Liang LinRea-Ming Yin;Ray H. Liu
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: hair analysis;amphetamines;drug deposition;drug abuse;GC-MS
    Date: 2005-09-01
    Issue Date: 2010-10-26 15:02:44 (UTC+8)
    Abstract: In this paper, the authors describe a sensitive method for simultaneous quantitation of amphetamine (AM), methamphetamine (MA), 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetanune (MDMA) in human hair by gas chromatography-mass spectrometry (GC-MS). Hair samples are initially cut into 0.5-cm sections, washed with methanol, and digested for 1 hr at 80℃ in 2 N NaOH and deuterated internal standards. The resulting solutions are processed with a liquid-liquid extraction procedure and further derivatized with heptafluorobutyric anhydride (HFBA) before undergoing GC/MS analysis. The overall protocol achieves the following results when applied to the analysis of 50mg drug-free hair specimens fortified with 2-40ng/mg amphetamines recovery 77.45-86.86%, inter-day and intra-day precision ranges 0.55-7.73% and 0.76-4.79%, respectively, linearity r^2>0.997, detection limits: 0.05ng/mg for AM, MA, and MDMA and 0.1ng/mg for MDA, and quantitation limits: 0.1ng/mg for AM, MA, and MDMA and 0.2ng/mg for MDA. Data derived from our analysis of hair samples collected from 30 self-reported methamphetamine abusers range from 1.39 to 15.41 (mean±S.D., 5.21±3.25)ng/mg for amphetamine and 12.58 to 173.28 (mean±S.D., 56.10±36.85)ng/mg for methamphetamine. This method has also been utilized successfully to evaluate the deposition pattern of drugs in head hairs collected from six female methamphetamine abusers staying at a rehabilitation facility. We conclude that this relatively simple protocol can be used for routine and reliable identification and quantitation of AM, MA, MDA, and MDMA in hair.
    Relation: J Food Drug Analysis 13(3),193-200
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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