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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/8387


    Title: HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients
    Authors: J. C. C. Wei,;W. C. Tsai;H. S. Lin;C. Y. Tsai;C. T. Chou
    Contributors: 輔英科技大學 健康事業管理學位學程
    Keywords: Ankylosing spondylitis;HLA-B27-negative;HLA-class I genes
    Date: 2004-07
    Issue Date: 2010-10-27 14:17:39 (UTC+8)
    Abstract: Objectives:
     Carriage of HLA-B60 has been shown to increase the risk of ankylosing spondylitis (AS) in B27-positive Caucasian patients, but the association in B27-negative cases is less certain. This study assessed HLA class I gene associations in Chinese HLA-B27-negative AS patients.
    Method:
     Forty-one Chinese HLA-B27-negative AS patients fulfilling the modified New York diagnostic criteria for AS were recruited, and 11 383 HLA-B27-negative blood donors were used for comparison. HLA-A and -B typing was done with the microlymphocytotoxicity assay.
    Results:
     Among the B27-negative AS patients, 21 were male and 20 were female. Of HLA-B alleles, only B60 and B61 significantly increased susceptibility to AS in HLA-B27-negative patients (P<0.001).
    Conclusion:
     In Taiwan Chinese, carriage of B60 is increased in HLA-B27-negative AS patients. The association between B61 and HLA-B27-negative AS patients has not been reported previously. Whether the gene involved is HLA-B60 or B61 or another gene in linkage disequilibrium with these genes is unknown.
    Relation: Rheumatology 43(7),839-842
    Appears in Collections:[健康事業管理系] 期刊論文

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