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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/8520


    Title: Gas chromatography–mass spectrometry analysis of ketamine and its metabolites—A comparative study on the utilization of different derivatization groups.
    Authors: Chih-Hung Wu;Mei-Han Huang;Sheng-Meng Wang;Ching-Chiang Lin;Liu,Ray-H
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: Ketamine;Derivatization;GC–MS
    Date: 2007-07-01
    Issue Date: 2010-10-28 16:08:09 (UTC+8)
    Abstract: Method of chemical derivatization is the main difference among the GC–MS based methodologies reported for the analysis of ketamine and its major metabolites (norketamine and dehydronorketamine). These approaches included acylation and silylation resulting in the formation of acetyl, trifluoroacetyl, heptafluorobutyryl, and pentafluorobenzoyl (for acylation); and possibly trimethylsilyl and t-butyldimethylsilyl (for silylation) derivatives. This study evaluates the merits of these approaches based on the following criteria: reaction yields and ionization efficiency of the derivatization products; chromatographic characteristics; and cross-contributions to the intensities of ions designating the analyte and the internal standard. Pentafluorobenzoyl-derivatives were found to provide the best performance characteristics.
    Relation: J Chromatogr A 1157(1-2),336-351
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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