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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/8866


    Title: Cytotoxic Compounds from the Stems of Cinnamomum tenuifolium.
    Authors: Rong-Jyh Lin;Ming-Jen Cheng;Jin-Cherng Huang;Wen-Li Lo;Yu-Ting Yeh;Chung-Min Yen;Chin-Mei Lu;Chen, Chung-Yi
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Date: 2009-10-01
    Issue Date: 2010-11-05
    Abstract: Three new butanolides, tenuifolide A (1), isotenuifolide A (2), and tenuifolide B (3), a new secobutanolide, secotenuifolide A (4), and one new sesquiterpenoid, tenuifolin (5), along with 16 known compounds were isolated from the stems of Cinnamomum tenuifolium. Their structures were determined by spectroscopic analyses. Compound 4 was found to induce apoptotic-related DNA damage, increase sub-G1 cells, and inhibit the growth of human prostate cancer cells, DU145. In addition, treatment with 4 significantly increased intracellular H2O2 and/or peroxide. The results show that 4 induced (a) noticeable reduction of mitochondrial transmembrane potential (ΔΨm); (b) significant increase in the ratio of cytochrome c concentration (cytosol/mitochondria); and (c) subsequent activation of caspase-9/caspase-3. Antiproliferation caused by 4 was found to markedly decrease when pretreated with caspase-9/caspase-3 inhibitor. In ROS scavenging, antioxidant, NADPH oxidase, and NO inhibitor studies, pretreatment of DU145 cells with either DPI, dexamethasone, l-NAME, or mannitol decreased 4-induced intracellular DCF fluorescence of ROS. These results suggest that an increase of H2O2 and/or peroxide by 4 is the initial apoptotic event and 4 has anticancer effects on DU145 cells.
    Relation: Journal of Natural Products 72(10),1816-1824
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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