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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/9183


    Title: 6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells.
    Authors: Ya-Ling Hsu;Chung-Yi Chen;Ming-Feng Hou;Eing-Mei Tsai;Yuh-Jyh Jong;Chih-Hsing Hung;Po-Lin Kuo
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: 6-Dehydrogingerdione;Apoptosis;Cell cycle;c-Jun N-terminal kinase;Reactive oxygen species
    Date: 2010-09-01
    Issue Date: 2010-11-08 10:45:31 (UTC+8)
    Abstract: This study is the first to investigate the anticancer effect of 6-dehydrogingerdione (DGE), an active constituent of dietary ginger, in human breast cancer MDA-MB-231 and MCF-7 cells. DGE exhibited effective cell growth inhibition by inducing cancer cells to undergo G2/M phase arrest and apoptosis. Blockade of cell cycle was associated with increased levels of p21, and reduced amounts of cyclin B1, cyclin A, Cdc2 and Cdc25C. DGE also enhanced the levels of inactivated phosphorylated Cdc2 and Cdc25C. DGE triggered the mitochondrial apoptotic pathway indicated by a change in Bax/Bcl-2 ratios, resulting in caspase-9 activation. We also found the generation of reactive oxygen species is a critical mediator in DGE-induced cell growth inhibition. DGE clearly increased the activation of apoptosis signal-regulating kinase 1 and c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase 1/2 (ERK1/2) and p38. In addition, antioxidants vitamin C and catalase significantly decreased DGE-mediated JNK activation and apoptosis. Moreover, blocking JNK by specific inhibitors suppressed DGE-triggered mitochondrial apoptotic pathway. Taken together, these findings suggest that a critical role for reactive oxygen species and JNK in DGE-mediated apoptosis of human breast cancer.
    Relation: Molecular Nutrition and Food Research 54(9),1307-1317
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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