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    Please use this identifier to cite or link to this item: https://ir.fy.edu.tw:8080/ir/handle/987654321/9187


    Title: Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinical extensively drug-resistant Acinetobacter baumanii.
    Authors: Hui-Min Wang;Chen, Chung-Yi;Hsi-An Chen;Wan-Chun Huang;Wei-Ru Lin;Tun-Chieh Chen;Chun-Yu Lin;Hsin-Ju Chien;Po-Liang Lu;Chiu-Mei Lin;Yen-Hsu Chen
    Contributors: 輔英科技大學 醫學檢驗生物技術系
    Keywords: Zingiber offi cinale;Acinetobacter baumannii;extensively drug-resistant;antioxidant;antimicrobial activities.
    Date: 2010-12-01
    Issue Date: 2010-11-08 10:45:33 (UTC+8)
    Abstract: Extensively drug-resistant Acinetobacter baumannii (XDRAB) is a growing and serious nosocomial infection
    worldwide, such that developing new agents against it is critical. The antimicrobial activities of the rhizomes
    from Zingiber offi cinale, known as ginger, have not been proven in clinical bacterial isolates with extensive
    drug-resistance. This study aimed to investigate the effects of four known components of ginger, [6]-dehydrogingerdione,
    [10]-gingerol, [6]-shogaol and [6]-gingerol, against clinical XDRAB. All these compounds showed
    antibacterial effects against XDRAB. Combined with tetracycline, they showed good resistance modifying
    effects to modulate tetracycline resistance. Using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging
    method, these four ginger compounds demonstrated antioxidant properties, which were inhibited by MnO2, an
    oxidant without antibacterial effects. After the antioxidant property was blocked, their antimicrobial effects
    were abolished signifi cantly. These results indicate that ginger compounds have antioxidant effects that partially
    contribute to their antimicrobial activity and are candidates for use in the treatment of infections with XDRAB.
    Relation: Phytotherapy Research
    Appears in Collections:[醫學檢驗生物技術系] 期刊論文

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